ABSTRACT
Background: Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. Aim: To measure vitamin D levels in children with Hashimotos thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. Material and Methods: We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured. Results: Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001). Conclusions: Vitamin D deficiency is more common in children with HT than healthy controls.
Antecedentes: La deficiencia o insuficiencia de vitamina D puede tener un rol en la patogenia de enfermedades autoinmunes. Objetivo: Medir niveles de vitamina D en niños con tiroiditis de Hashimoto (TH) (con hipotiroidismo subclínico o marcado) y en controles sanos. Material y Métodos: Estudiamos 68 niños con TH, de 12 ± 4 años (39 mujeres) y 68 controles sanos de 10 ± 4 años (37 mujeres). Se les midió parámetros de metabolismo de calcio, pruebas de función tiroidea, anticuerpos anti peroxidasa y anti tiroglobulina y 25 hidroxi vitamina D (25 OH vit D). Resultados: Los pacientes eran mayores que los controles pero la distribución por género era homogénea en ambos grupos. Los niveles de 25 OH vit D en pacientes y controles fueron 16,8 ± 9,3 y 24,1 ± 9,4 ng/mL respectivamente, p < 0,01. La frecuencia de deficiencia de vitamina D fue de 76 y 35% en pacientes y controles, respectivamente. Conclusiones: La deficiencia de vitamina D es más común en niños con TH.
Subject(s)
Humans , Male , Female , Child , Autoantibodies/blood , Vitamin D Deficiency/complications , 25-Hydroxyvitamin D 2/blood , Hashimoto Disease/complications , Autoantibodies/immunology , Vitamin D Deficiency/diagnosis , Vitamin D Deficiency/blood , Case-Control Studies , Hashimoto Disease/blood , Iodide Peroxidase/immunology , Iodide Peroxidase/bloodABSTRACT
OBJECTIVES: Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly. METHODS: We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans > or =60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times. RESULTS: The association of vitamin D and hs-CRP was significant after adjusting for known confounders (beta=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: beta=-0.375, p=0.013; non-smokers: beta=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: beta=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (beta=0.003, p=0.805). CONCLUSIONS: Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association. Vitamin D deficiency was not significantly associated with WBC count.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , 25-Hydroxyvitamin D 2/blood , Biomarkers/blood , Body Mass Index , C-Reactive Protein/analysis , Inflammation , Leukocyte Count , Smoking , Urban Population , Vitamin D/blood , Vitamin D Deficiency/diagnosisABSTRACT
No abstract available.
Subject(s)
Humans , 25-Hydroxyvitamin D 2/blood , Cholecalciferol/blood , Chromatography, High Pressure Liquid , Radioimmunoassay , Reagent Kits, Diagnostic , Tandem Mass SpectrometryABSTRACT
Patients with chronic lung disease as asthma appear to be at increased risk for vitamin D deficiency for reasons that are not clear. A cross sectional study including 75 asthmatic adults aged older than 18 years and 75 adults healthy control aged older than 18 years [35 males and 40 females for both groups] assessing the relationship between serum 25 hydroxy vitamin D levels and lung function. In our study only [12.31%] of our asthmatic adults had sufficient vitamin D levels [>/=30 ng/ml], wherase [85%] of healthy control subjects expressed sufficient levels. Vitamin D deficiency [<20 ng/ml] was observed in 59 [78.66%] asthmatic patients [17.28 +/- 2.4 ng/ml]. Deficiency was not observed in controls [33.67 +/- 6.3]. In asthmatic patients Serum 25 [OH] vitamin D was positively correlated with forced expiratory volume in 1 second% [FEV1%] predicted andforced expiratory/forced vital capacity ratio [FEV1/FVC][P=<0.05 for all]. There was no significant association between serum vitamin D level and eosinophil count. Reduced vitamin D levels are highly prevalent in adult asthmatic patients and are associated with impaired pulmonary functions
Subject(s)
Humans , Male , Female , Respiratory Function Tests , 25-Hydroxyvitamin D 2/bloodABSTRACT
Vitamin D deficiency is common in Arab women, In a pilot study we investigated the effect of sun exposure at recommended levels on the vitamin D status of Arab women. Eight healthy Arab women of child-bearing age consented to expose their face, arms and hands for 15 minutes per day twice a week for 4 weeks within the privacy of their courtyard and to avoid changes in dietary vitamin D intake. Serum 25-hydroxyvitamin D [25[OH]] levels were measured pre- and post-intervention. Although vitamin D levels remained sub-optimal, median serum 25[OH]D levels were significantly higher post-intervention [23.0 nmol/L] than pre-intervention [17.6 nmol/L]. Extending sun exposure for more than 4 weeks should be investigated as part of strategies to improve vitamin D status in high-risk Arab women who lack outdoor sun exposure to the skin
Subject(s)
Humans , Female , Adult , Vitamin D/blood , Vitamin D Deficiency , Women , Arabs , 25-Hydroxyvitamin D 2/bloodABSTRACT
BACKGROUND: The VDR protein is at the centre of the vitamin D endocrine system, a complex physiological system with substantial feedback regulatory mechanisms involved in maintaining serum calcium and 1, 25 dihydroxy vitamin D3. Variations in VDR gene are shown to have implications in several diseases and have also been implicated as an important genetic factor affecting bone mass. AIM: To determine the frequency of Fok I and Taq I variants in healthy Indian individuals and its association with 25-OH-Vitamin D levels. SETTINGS AND DESIGN: Blood samples were collected from 143 unrelated normal individuals (Male-84 and Female-59) and their genotypes determined. MATERIALS AND METHODS: After amplification by polymerase chain reaction, each polymorphism was genotyped by restriction fragment length polymorphism. For 100 normal healthy individuals 25-hydroxyvitamin D estimation was done using DiaSorin kit method. STATISTICAL ANALYSIS: Graph pad software was used to calculate the P values from the Chi-square. RESULTS: Out of 143 samples analyzed for FokI and TaqI polymorphisms the following genotypic frequency was obtained FF 59%, Ff 36%, ff 5% and TT 49%, Tt 43%, tt 8% respectively. CONCLUSIONS: Results indicate that the distribution of the polymorphic loci Fok I and Taq I vary considerably not only in different populations, but also within India. Furthermore, when the genotypes were analyzed with respect to 25-OH-Vitamin D levels, a significant association was seen for the Taq 1 SNP but not with the Fok I.
Subject(s)
25-Hydroxyvitamin D 2/blood , 25-Hydroxyvitamin D 2/genetics , Female , Genetic Association Studies , Humans , India , Male , Polymorphism, Genetic , Polymorphism, Single Nucleotide , Receptors, Calcitriol/blood , Receptors, Calcitriol/genetics , Taq Polymerase , Vitamin D/blood , Vitamin D/metabolismABSTRACT
Micronutrient deficiencies exist among women of childbearing age in the United Arab Emirates but the effects of maternal micronutrient deficiency on fetal growth are not well documented. To investigate the association between micronutrients and birth weight, we measured maternal and cord blood micronutrients [vitamin A, C, D, and E] and ferritin in 84 term, singleton infants born to healthy Arab and South Asian women at Al-Ain hospital. Median serum ascorbic acid and 25-hydroxyvitamin D [25-OHD] concentrations were low in mothers and infants. In multivariate analysis, maternal serum 25-OHD correlated positively with birth weight while serum ferritin showed a negative correlation
Subject(s)
Female , Humans , Nutritional Status , Birth Weight , Infant , Mothers , Ferritins/blood , Ascorbic Acid/blood , 25-Hydroxyvitamin D 2/blood , Vitamin D DeficiencyABSTRACT
25-hydroxyvitamin D has a longer half life and its serum levels have less daily variations than calcitrol. Thus, its measurement is a better indicator of vitamin D status. Vitamin D was measured using a competitive protein binding radioassay in 61 subjects (27 males) aged 21 to 57 years old, during july to august (winter) and february and march of the next year (summer). 25-hydroxyvitamin levels were 28.8ñ1.5 and 30.9ñ2.3 ng/ml during winter and summer respectively. No differences were found between men and women. Ninety five percent confidence levels were between 13 and 50 ng/ml. Levels in 1 patient with malabsorption were 9.3 ng/ml, in 2 patients with hypophosphemic osteomalacia were 2.1 and 9.3 ng/ml, in 12 patients with alcoholic cirrhosis were 16.4ñ1.3 ng/ml, in 4 patients with primary osteoporosis were 23.3ñ0.7 and in 3 patients receiving vitamin D were 334ñ33.2 ng/ml. Normal levels of 25-hydroxyvitamin D range from 13 to 50 ng/ml in normal adults, there are no differences between men and women and seasonal variations are minimal
Subject(s)
Humans , Male , Female , Adult , Middle Aged , 25-Hydroxyvitamin D 2/blood , Radioligand Assay , Reference Values , Vitamin D Deficiency/prevention & controlSubject(s)
Humans , Female , Middle Aged , 25-Hydroxyvitamin D 2/blood , Femur Neck/chemistry , Menopause , Bone DensityABSTRACT
A 25-hidroxivitamina D de 441 índios de seis aldeamentos indígenas da Amazônia Oriental foi determinada usando-se um ensaio competitivo de proteína ligadora com prévia cromatografia. Os resultados foram comparados com os obtidos de uma populaçäo caucasóide da cidade de Säo Paulo. Os valores médios e seis grupos indígenas foram maiores que o valor médio da populaçäo caucasóide, sendo que em três grupos indígenas a diferença foi estatisticamente significante.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , 25-Hydroxyvitamin D 2/blood , Indians, South American , Analysis of Variance , Brazil , Nutritional Status/physiology , Statistics, NonparametricABSTRACT
Para analizar la mayor incidencia de raquitismo nutricional en el Sur de la Argentina, se estudiaron durante el mes de agosto niños clínicamente sanos de edad promedio siete años de Buenos Aires (n = 37) y de Ushuaia (n = 63). Se midieron niveles séricos de calcio, fósforo, fosfatasa alcalina y 25-OH-D. Además, se determinaron los niveles de este metabolito en un grupo de 29 niños de Buenos Aire de edad promedio 13 años. Los valores de 25-OH-D fueron significativamente menores (p < 0.001) en Ushuaia: (xñ1ES)9.3ñ0.64ng/ml que en los dos grupos etarios de Buenos Aires: 21.1 ñ 2.03 ng/ml y 19.0ñ1.18ng/ml. No hubo diferencias entrre los niveles de calcemia y fosfatasemia alcalina. La fosfatemia fue mayor en los niños de Ushuaia. La ingesta cálcica que fue mayor en Ushuaia se correlacionó positivamente en esta zona con los niveles de 25-OH-D. En síntesis, los niños sanos de Ushuaia tienen niveles de 25-OH-D disminuidos al final del invierno, debido probablemente al menor número de horas de sol disponible y a una menor radiación ultravioleta efectiva para la síntesis en piel de vitamina D